Ligand · FZS

FZS · (2R)-2-[(1S)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-2-hydroxyethyl]-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid

FZS, (2R)-2-[(1S)-1-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}-2-hydroxyethyl]-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid (C14 H17 N5 O5 S2, 399.4 g/mol), in the MolNFT structures on GenesisL1: bound…

Component: FZS
Formula: C14 H17 N5 O5 S2
Class: ligand
Structures: 4
PDB entries: 4

Binding sites

FZS in 4 structures; the first of them:

6B68 · Beta-Lactamase, 100ms timepoint, mixed, shards crystal form · FZS B302 · binds GLN109, CYS69, SER70, LYS73, ILE103, SER128, GLU168, PRO169 and 10 more
6B69 · Beta-Lactamase, 500ms timepoint, mixed, shards crystal form · FZS D302 · binds GLN109, CYS69, SER70, LYS73, ILE103, SER128, PRO169, ASN172 and 9 more
6B6D · Beta-Lactamase, mixed with Ceftriaxone, needles crystal form, 100ms · FZS A301 · binds CYS69, SER70, LYS73, ILE103, SER128, GLU168, PRO169, ASN172 and 9 more
6B6E · Beta-Lactamase, mixed with Ceftriaxone, needles crystal form, 500ms · FZS A301 · binds CYS69, SER70, ILE103, SER128, GLU168, PRO169, ASN172, ARG173 and 8 more

Residues it binds most

THR 4, ARG 4, GLY 4, SER 4, LYS 4, ASN 4, ASP 4, CYS 4, ILE 4, PRO 4 (residue and the binding sites it lines).

Found with

9F2 · Ceftriaxone
PO4 · Phosphate ion
CUG · (2R)-2-[(S)-{[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}(carboxy)methyl]-5-(hydroxymethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid

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