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Ligand · FZF

FZF · 4-(cyclohexylamino)-2-[(2-methoxy-4-morpholin-4-ylcarbonyl-phenyl)amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

FZF, 4-(cyclohexylamino)-2-[(2-methoxy-4-morpholin-4-ylcarbonyl-phenyl)amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (C25 H29 N7 O3, 475.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component
FZF
Formula
C25 H29 N7 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

FZF in 2 structures; the first of them:

  • 7CHM · Crystal structure of TTK kinase domain in complex with compound 8 · FZF A801 · binds ILE531, GLY532, VAL539, GLN541, ALA551, LYS553, ILE586, MET602 and 14 more
  • 7CHM · Crystal structure of ttk kinase domain in complex with compound 8 · FZF A801 · binds ILE531, GLY532, VAL539, GLN541, ALA551, MET602, GLU603, CYS604 and 9 more

Residues it binds most

ILE 2, GLN 2, GLY 2, ALA 2, ASP 2, MET 2, ASN 2, CYS 2, GLU 2, LEU 2 (residue and the binding sites it lines).

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