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Ligand · FWL

FWL · 3-[5-(aminomethyl)-4-(carboxymethyl)-2-iodo-1H-pyrrol-3-yl]propanoic acid

FWL, 3-[5-(aminomethyl)-4-(carboxymethyl)-2-iodo-1H-pyrrol-3-yl]propanoic acid (C10 H13 I N2 O4, 352.1 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries). Every binding site with its residues within 4.5 Å…

Component
FWL
Formula
C10 H13 I N2 O4
Class
ligand
Structures
3
PDB entries
2

Binding sites

FWL in 3 structures; the first of them:

  • 7CD0 · Crystal structure of the 2-iodoporphobilinogen-bound ES2 intermediate form of human… · FWL B402 · binds ARG26, SER28, LEU30, GLN34, SER96, ASP99, GLY168, ASN169 and 2 more
  • 7CCY · Crystal structure of the 2-iodoporphobilinogen-bound holo form of human… · FWL C401 · binds ARG26, SER28, LEU30, GLN34, LEU68, PHE77, SER96, ASP99 and 5 more
  • 7CD0 · Crystal structure of the 2-iodoporphobilinogen-bound ES2 intermediate form of human… · FWL B402 · binds ARG26, SER28, LEU30, GLN34, SER96, ASP99, GLY168, ASN169 and 2 more

Residues it binds most

ARG 3, LEU 3, SER 3, ASN 3, ASP 3, GLN 3, GLY 3, PHE 1 (residue and the binding sites it lines).

Found with

  • 7J8 · 3-[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-5-[[4-(2-hydroxy-2-oxoethyl)-3-(3-hydroxy-3-oxopropyl)-5-methyl-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-3-(3-hydroxy-3-oxopropyl)-1~{H}-pyrrol-2-yl]methyl]-1~{H}-pyrrol-3-yl]propanoic acid
  • DPM · 3-[5-{[3-(2-carboxyethyl)-4-(carboxymethyl)-5-methyl-1H-pyrrol-2-yl]methyl}-4-(carboxymethyl)-1H-pyrrol-3-yl]propanoic acid

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