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Ligand · FU7

FU7 · 2-amino-4-{2,4-dichloro-6-[2-(1H-pyrazol-1-yl)ethoxy]phenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide

FU7, 2-amino-4-{2,4-dichloro-6-[2-(1H-pyrazol-1-yl)ethoxy]phenyl}-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide (C21 H21 Cl2 F2 N7 O2, 512.3 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records…

Component
FU7
Formula
C21 H21 Cl2 F2 N7 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

FU7 in 2 structures; the first of them:

  • 3R4P · Optimization of potent, selective, and orally bioavailable… · FU7 A901 · binds ASN51, SER52, ASP54, ALA55, LYS58, ASP93, ILE96, GLY97 and 9 more
  • 3R4P · Optimization of potent, selective, and orally bioavailable… · FU7 A901 · binds ASN51, SER52, ASP54, ALA55, LYS58, ASP93, ILE96, GLY97 and 9 more

Residues it binds most

ASP 4, ASN 4, VAL 4, ALA 4, GLY 4, ILE 4, LEU 4, LYS 4, MET 4, PHE 4 (residue and the binding sites it lines).

Found with

  • PO4 · Phosphate ion

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