GL1X · GenesisL1 explorer

Ligand · FRS

FRS · 1-[5-methyl-2-(trifluoromethyl)furan-3-yl]-3-[(2Z)-5-(2-{[6-(1H-1,2,4-triazol-3-ylamino)pyrimidin-4-yl]amino}ethyl)-1,3-thiazol-2(3H)-ylidene]urea

FRS, 1-[5-methyl-2-(trifluoromethyl)furan-3-yl]-3-[(2Z)-5-(2-{[6-(1H-1,2,4-triazol-3-ylamino)pyrimidin-4-yl]amino}ethyl)-1,3-thiazol-2(3H)-ylidene]urea (C18 H17 F3 N10 O2 S, 494.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2…

Component
FRS
Formula
C18 H17 F3 N10 O2 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

FRS in 2 structures; the first of them:

  • 3DB6 · Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain… · FRS A1 · binds LEU45, GLY46, LYS47, ALA51, CYS53, ALA66, LYS68, VAL70 and 15 more
  • 3DB6 · Crystal structure of an activated (thr->asp) polo-like kinase 1 (PLK1) catalytic domain… · FRS A1 · binds LEU45, GLY46, LYS47, ALA51, CYS53, ALA66, LYS68, VAL70 and 15 more

Residues it binds most

VAL 2, ALA 2, CYS 2, GLU 2, GLY 2, ILE 2, LEU 2, LYS 2, PHE 2, ARG 2 (residue and the binding sites it lines).

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