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Ligand · FQN

FQN · 8-[4-(1-cyclopentylpiperidin-4-yl)pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one

FQN, 8-[4-(1-cyclopentylpiperidin-4-yl)pyrazol-1-yl]-3~{H}-pyrido[3,4-d]pyrimidin-4-one (C20 H24 N6 O, 364.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5…

Component
FQN
Formula
C20 H24 N6 O
Class
ligand
Structures
4
PDB entries
2

Binding sites

FQN in 4 structures; the first of them:

  • 6H4V · Crystal structure of human KDM4A in complex with compound 34g · FQN A403 · binds TYR132, ASP135, TYR177, PHE185, HIS188, GLU190, ASN198, LYS206 and 3 more
  • 6H52 · Crystal structure of human KDM5B in complex with compound 34g · FQN A813 · binds ARG98, TYR425, TRP486, TYR488, PHE496, HIS499, GLU501, ASN509 and 3 more
  • 6H4V · Crystal structure of human KDM4A in complex with compound 34G · FQN A403 · binds TYR132, ASP135, TYR177, PHE185, HIS188, GLU190, LYS206, TRP208 and 2 more
  • 6H52 · Crystal structure of human KDM5B in complex with compound 34G · FQN A813 · binds TYR425, TRP486, TYR488, PHE496, HIS499, GLU501, ASN509, LYS517 and 2 more

Residues it binds most

TYR 10, HIS 10, LYS 10, GLU 10, TRP 10, PHE 10, ASP 8, ASN 7, GLY 3, ARG 1 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • DMS · Dimethyl sulfoxide
  • MN · Manganese (II) ion
  • CL · Chloride ion
  • PO4 · Phosphate ion
  • EDO · 1,2-ethanediol

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