Ligand · FLW

FLW · 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxyethyl)propyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one

FLW, 6-(2,4-difluorophenoxy)-2-{[3-hydroxy-1-(2-hydroxyethyl)propyl]amino}-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (C19 H20 F2 N4 O4, 406.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component: FLW
Formula: C19 H20 F2 N4 O4
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

FLW in 2 structures; the first of them:

3FLW · P38 kinase crystal structure in complex with pamapimod · FLW A361 · binds VAL30, SER32, GLY33, ALA34, VAL38, ALA51, VAL52, LYS53 and 15 more
3FLW · P38 kinase crystal structure in complex with pamapimod · FLW A361 · binds VAL30, SER32, GLY33, ALA34, VAL38, ALA51, VAL52, LYS53 and 15 more

Residues it binds most

LEU 2, ALA 2, VAL 2, GLY 2, SER 2, ASP 2, HIS 2, ILE 2, LYS 2, MET 2 (residue and the binding sites it lines).

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