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Ligand · FH0

FH0 · ~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{H}-pyrazolo[5,1-c][1,4]oxazin-3-yl) pyrimidin-2-amine

FH0, ~{N}-[4-(4-methylpiperazin-1-yl)phenyl]-4-(2-pyridin-3-yl-6,7-dihydro-4~{H}-pyrazolo[5,1-c][1,4]oxazin-3-yl) pyrimidin-2-amine (C26 H28 N8 O, 468.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
FH0
Formula
C26 H28 N8 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

FH0 in 2 structures; the first of them:

  • 7C3G · Crystal structure of human ALK2 kinase domain with R206H mutation in complex with a… · FH0 A501 · binds VAL214, TYR219, VAL222, ALA233, LYS235, LEU263, LEU281, THR283 and 11 more
  • 7C3G · Crystal structure of human ALK2 kinase domain with R206H mutation in complex with a… · FH0 A501 · binds VAL214, TYR219, VAL222, ALA233, LYS235, LEU263, LEU281, THR283 and 10 more

Residues it binds most

LEU 4, HIS 4, LYS 4, VAL 4, TYR 4, ALA 4, ASP 4, GLU 4, GLY 4, MET 4 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • EDO · 1,2-ethanediol

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