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Ligand · F1S

F1S · N-(5-{[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl]amino}-2-chloropyridin-3-yl)methanesulfonamide

F1S, N-(5-{[3-(4-amino-6-methyl-1,3,5-triazin-2-yl)-5-(tetrahydro-2H-pyran-4-yl)pyridin-2-yl]amino}-2-chloropyridin-3-yl)methanesulfonamide (C20 H23 Cl N8 O3 S, 491.0 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
F1S
Formula
C20 H23 Cl N8 O3 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

F1S in 2 structures; the first of them:

  • 4F1S · Crystal structure of human PI3K-gamma in complex with a pyridyl-triazine-sulfonamide… · F1S A1207 · binds MET804, SER806, LYS808, PRO810, TRP812, ILE831, LYS833, LEU838 and 13 more
  • 4F1S · Crystal structure of human PI3K-gamma in complex with a pyridyl- triazine-sulfonamide… · F1S A1207 · binds MET804, SER806, LYS808, PRO810, TRP812, ILE831, LYS833, LEU838 and 13 more

Residues it binds most

ILE 2, LYS 2, ASP 2, MET 2, ALA 2, GLU 2, LEU 2, PHE 2, PRO 2, SER 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion

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