Ligand · ETU

ETU · (3R)-4-(2-{4-[1-(3-chloro[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidinyl]phenoxy}ethyl)-1,3-dimethyl-2-piperazinone

ETU, (3R)-4-(2-{4-[1-(3-chloro[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidinyl]phenoxy}ethyl)-1,3-dimethyl-2-piperazinone (C24 H30 Cl N7 O2, 484.0 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component: ETU
Formula: C24 H30 Cl N7 O2
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

ETU in 2 structures; the first of them:

5AD2 · Bivalent binding to BET bromodomains · ETU A1169 · binds TRP81, PRO82, PHE83, VAL87, LEU92, LEU94, TYR97, CYS136 and 15 more
5AD2 · Bivalent binding to bet bromodomains · ETU A1169 · binds TRP81, PRO82, PHE83, VAL87, LEU92, LEU94, TYR97, CYS136 and 15 more

Residues it binds most

LEU 2, TYR 2, ASN 2, ASP 2, ILE 2, PHE 2, PRO 2, VAL 2, CYS 2, MET 2 (residue and the binding sites it lines).

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