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Ligand · EP2

EP2 · methyl N-[(2S)-4-{[(1S)-1-{[(2S)-2-carboxypyrrolidin-1-yl]carbonyl}-3-methylbutyl]amino}-2-hydroxy-4-oxobutanoyl]-L-leucylglycylglycinate

EP2, methyl N-[(2S)-4-{[(1S)-1-{[(2S)-2-carboxypyrrolidin-1-yl]carbonyl}-3-methylbutyl]amino}-2-hydroxy-4-oxobutanoyl]-L-leucylglycylglycinate (C26 H41 N5 O10, 583.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
EP2
Formula
C26 H41 N5 O10
Class
ligand
Structures
2
PDB entries
1

Binding sites

EP2 in 2 structures; the first of them:

  • 1SP4 · Crystal structure of NS-134 in complex with bovine cathepsin B: a two headed… · EP2 B48 · binds GLN23, GLY24, CYS26, GLY27, SER28, CYS29, TRP30, GLY73 and 15 more
  • 1SP4 · Crystal structure of ns-134 in complex with bovine cathepsin B: a two headed… · EP2 B48 · binds GLN23, GLY24, CYS26, GLY27, SER28, CYS29, TRP30, GLY73 and 15 more

Residues it binds most

GLY 2, HIS 2, ALA 2, CYS 2, GLU 2, TRP 2, GLN 2, MET 2, PHE 2, PRO 2 (residue and the binding sites it lines).

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