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Ligand · EDS

EDS · (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-{[(2S,3R)-3-amino-6-{[(2-hydroxyethyl)amino]methyl}-3,4-dihydro-2H-pyran-2-yl]oxy}-2-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide

EDS, (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-{[(2S,3R)-3-amino-6-{[(2-hydroxyethyl)amino]methyl}-3,4-dihydro-2H-pyran-2-yl]oxy}-2-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-3-hydroxycyclohexyl]-2-hydroxybutanamide…

Component
EDS
Formula
C25 H48 N6 O10
Class
ligand
Structures
3
PDB entries
2

Binding sites

EDS in 3 structures; the first of them:

  • 6CD7 · Crystal structure of APH(2)-IVa in complex with plazomicin" · EDS B401 · binds ASN32, ASP197, ASP220, GLU235, GLU238, GLU268, TRP271, TYR278 and 2 more
  • 7LH5 · Crystal structure of the Thermus thermophilus 70S ribosome in complex with plazomicin… · EDS AA1805 · binds C1404, G1405, U1406, C1407, A1408, G1491, A1493, G1494 and 5 more
  • 6CD7 · Crystal structure of APH(2")-iva in complex with plazomicin · EDS B401 · binds ASN32, ASP220, GLU235, GLU238, GLU268, TRP271, TYR284, TRP287

Residues it binds most

C 2, G 2, A 2, GLU 2, U 2, TRP 2, ASP 2, TYR 2, ASN 2 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion
  • MG · Magnesium ion
  • ZN · Zinc ion

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