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Ligand · ED7

ED7 · N-benzyl-N-(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)-2-methylbenzenesulfonamide

ED7, N-benzyl-N-(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)-2-methylbenzenesulfonamide (C28 H29 N5 O2 S, 499.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with…

Component
ED7
Formula
C28 H29 N5 O2 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

ED7 in 2 structures; the first of them:

  • 3E33 · Protein farnesyltransferase complexed with FPP and ethylenediamine scaffold inhibitor 7 · ED7 B1003 · binds TYR166, TYR93, LEU96, SER99, TRP102, TRP106, ARG202, ASP297 and 7 more
  • 3E33 · Protein farnesyltransferase complexed with fpp and ethylenediamine scaffold inhibitor 7 · ED7 B1003 · binds TYR166, TYR93, LEU96, SER99, TRP102, TRP106, ARG202, ASP297 and 7 more

Residues it binds most

TYR 2, ASP 2, TRP 2, ARG 2, CYS 2, HIS 2, LEU 2, PHE 2, SER 2 (residue and the binding sites it lines).

Found with

  • FPP · Farnesyl diphosphate
  • ZN · Zinc ion

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