Ligand · ED5
ED5 · tert-butyl 4-({(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)[(2-methylphenyl)sulfonyl]amino}methyl)piperidine-1-carboxylate
ED5, tert-butyl 4-({(2-{(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino}ethyl)[(2-methylphenyl)sulfonyl]amino}methyl)piperidine-1-carboxylate (C32 H42 N6 O4 S, 606.8 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records…
- Component
- ED5
- Formula
- C32 H42 N6 O4 S
- Class
- ligand
- Structures
- 4
- PDB entries
- 2
Binding sites
ED5 in 4 structures; the first of them:
- 3E37 · Protein farnesyltransferase complexed with bisubstrate ethylenediamine scaffold inhibitor… · ED5 B1 · binds TYR166, LEU98, TRP104, TRP108, ALA153, TYR156, ARG204, TYR207 and 14 more
- 4LNB · Aspergillus fumigatus protein farnesyltransferase ternary complex with… · ED5 B603 · binds TYR109, PHE166, ALA168, LEU169, SER172, TRP179, ARG274, TYR336 and 6 more
- 3E37 · Protein farnesyltransferase complexed with bisubstrate ethylenediamine scaffold inhibitor… · ED5 B1 · binds TYR166, LEU98, TRP104, TRP108, ALA153, TYR156, ARG204, TYR207 and 14 more
- 4LNB · Aspergillus fumigatus protein farnesyltransferase ternary complex with… · ED5 B603 · binds TYR109, PHE166, ALA168, LEU169, SER172, TRP179, ARG274, TYR336 and 6 more
Residues it binds most
TYR 4, ASP 4, CYS 4, TRP 4, HIS 4, ALA 4, ARG 4, LEU 4, PHE 4, GLY 2 (residue and the binding sites it lines).
Found with
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