Ligand · ECM

ECM · 7-{8-chloro-11-[3-(4-chloro-3,5-dimethylphenoxy) propyl]-1-oxo-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-[1,4]diazepino[1,2-a]indol-2(3H)-yl}-1-methyl-1H-indole-3-carboxylic acid

ECM, 7-{8-chloro-11-[3-(4-chloro-3,5-dimethylphenoxy) propyl]-1-oxo-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-[1,4]diazepino[1,2-a]indol-2(3H)-yl}-1-methyl-1H-indole-3-carboxylic acid (C39 H39 Cl2 N5 O4, 712.7 g/mol), in the…

Component: ECM
Formula: C39 H39 Cl2 N5 O4
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

ECM in 2 structures; the first of them:

6BW8 · Mcl-1 complexed with small molecules · ECM A400 · binds HIS224, ALA227, PHE228, MET231, MET250, VAL253, PHE254, VAL258 and 9 more
6BW8 · Mcl-1 complexed with small molecules · ECM A400 · binds HIS224, ALA227, PHE228, MET231, MET250, VAL253, PHE254, VAL258 and 9 more

Residues it binds most

PHE 8, LEU 8, MET 8, VAL 8, ARG 8, GLY 8, HIS 6, ALA 8, ASN 6, THR 6 (residue and the binding sites it lines).

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