Ligand · E8H
E8H · 1-(2-{4-[(4as,8ar)-4-(3,4-dimethoxyphenyl)-1-oxo-1,2, 4A,5,8,8A-hexahydrophthalazin-2-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione
E8H, 1-(2-{4-[(4as,8ar)-4-(3,4-dimethoxyphenyl)-1-oxo-1,2, 4A,5,8,8A-hexahydrophthalazin-2-yl]piperidin-1-yl}-2-oxoethyl)pyrrolidine-2,5-dione (C27 H32 N4 O6, 508.6 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB…
- Component
- E8H
- Formula
- C27 H32 N4 O6
- Class
- ligand
- Structures
- 3
- PDB entries
- 2
Binding sites
E8H in 3 structures; the first of them:
- 6FV9 · Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-007 · E8H A1006 · binds TYR668, MET785, ASP822, ILE823, ASN825, TRP836, ALA837, VAL840 and 6 more
- 6FV9 · Crystal structure of T. brucei pde-B1 catalytic domain with inhibitor npd-007 · E8H A1006 · binds TYR668, MET785, ASP822, ILE823, ASN825, TRP836, ALA837, VAL840 and 6 more
- 6FW3 · Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor npd-007 · E8H A523 · binds HIS160, MET273, ASP318, LEU319, ASN321, ILE336, MET357, GLN369 and 2 more
Residues it binds most
MET 8, PHE 8, ILE 8, ASN 8, GLN 8, GLY 8, ASP 7, VAL 4, TRP 5, TYR 5 (residue and the binding sites it lines).
Found with
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