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Ligand · E6U

E6U · N-[(1S)-1-benzyl-2-(3-guanidinopropylamino)-2-oxo-ethyl]-4-hydroxy-2-oxo-1H-quinoline-6-carboxamide

E6U, N-[(1S)-1-benzyl-2-(3-guanidinopropylamino)-2-oxo-ethyl]-4-hydroxy-2-oxo-1H-quinoline-6-carboxamide (C23 H26 N6 O4, 450.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
E6U
Formula
C23 H26 N6 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

E6U in 2 structures; the first of them:

  • 4D7G · Human FXIa in complex with small molecule inhibitors. · E6U A1250 · binds ARG37D, HIS38, LEU39, CYS40, HIS57, CYS58, TYR143, ILE151 and 15 more
  • 4D7G · Human fxia in complex with small molecule inhibitors. · E6U A1250 · binds ARG37D, HIS38, LEU39, CYS40, HIS57, CYS58, TYR143, ILE151 and 15 more

Residues it binds most

CYS 2, GLY 2, ASP 2, HIS 2, SER 2, ALA 2, ARG 2, ILE 2, LEU 2, LYS 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • GOL · Glycerol
  • TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol

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