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Ligand · E55

E55 · 3-O-decyl-2-deoxy-6-O-{2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[(11Z)-octadec-11-enoylamino]-4-O-phosphono-beta-D-glucopyranosyl}-2-[(3-oxotetradecanoyl)amino]-1-O-phosphono-alpha-D-glucopyranose

E55, 3-O-decyl-2-deoxy-6-O-{2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[(11Z)-octadec-11-enoylamino]-4-O-phosphono-beta-D-glucopyranosyl}-2-[(3-oxotetradecanoyl)amino]-1-O-phosphono-alpha-D-glucopyranose (C66 H126 N2 O19 P2, 1313.7…

Component
E55
Formula
C66 H126 N2 O19 P2
Class
ligand
Structures
4
PDB entries
2

Binding sites

E55 in 4 structures; the first of them:

  • 2Z65 · Crystal structure of the human TLR4 TV3 hybrid-MD-2-Eritoran complex · E55 C1 · binds ILE32, ILE46, VAL48, ILE52, LEU61, ILE63, TYR65, LEU71 and 20 more
  • 3ULA · Crystal structure of the TV3 mutant F63W-MD-2-Eritoran complex · E55 A1206 · binds CYS264, CYS266, LYS294, PRO295, SER298, ILE299, ILE300, CYS301 and 30 more
  • 2Z65 · Crystal structure of the human TLR4 TV3 hybrid-md-2-eritoran complex · E55 C1 · binds ILE32, ILE46, VAL48, ILE52, LEU61, ILE63, TYR65, LEU71 and 20 more
  • 3ULA · Crystal structure of the TV3 mutant F63W-md-2-eritoran complex · E55 A1206 · binds CYS264, CYS266, LYS294, PRO295, SER298, ILE299, ILE300, CYS301 and 30 more

Residues it binds most

ILE 8, PHE 8, LEU 8, SER 8, TYR 8, VAL 8, CYS 8, LYS 8, GLY 8, PRO 4 (residue and the binding sites it lines).

Found with

  • BMA · beta-D-mannopyranose
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose

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