Ligand · E3W

E3W · 4'-{[5-amino-3-(4-sulfamoylanilino)-1H-1,2,4-triazole-1-carbonyl]amino}-4-(benzyloxy)[1,1'-biphenyl]-3-carboxylic acid

E3W, 4'-{[5-amino-3-(4-sulfamoylanilino)-1H-1,2,4-triazole-1-carbonyl]amino}-4-(benzyloxy)[1,1'-biphenyl]-3-carboxylic acid (C29 H25 N7 O6 S, 599.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component: E3W
Formula: C29 H25 N7 O6 S
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

E3W in 2 structures; the first of them:

7T0P · JAK2 JH2 in complex with JAK315 · E3W A901 · binds LEU551, GLY554, THR555, THR557, ILE559, LEU579, LYS581, VAL610 and 17 more
7T0P · JAK2 JH2 in complex with JAK315 · E3W A901 · binds LEU551, GLY554, THR555, THR557, ILE559, LEU579, LYS581, VAL610 and 17 more

Residues it binds most

LEU 4, LYS 4, THR 4, ASN 4, GLY 4, PHE 4, SER 4, VAL 4, ARG 4, CYS 4 (residue and the binding sites it lines).

Found with

GOL · Glycerol

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