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Ligand · DXQ

DXQ · 7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine

DXQ, 7-[3-(dimethylamino)propoxy]-6-methoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-(1-methylpiperidin-4-yl)quinazolin-4-amine (C26 H43 N7 O2, 485.7 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component
DXQ
Formula
C26 H43 N7 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

DXQ in 2 structures; the first of them:

  • 3K5K · Discovery of a 2,4-Diamino-7-aminoalkoxy-quinazoline as a Potent Inhibitor of Histone… · DXQ A2000 · binds ASP1074, ALA1077, ASP1078, ARG1080, ASP1083, SER1084, TYR1085, LEU1086 and 9 more
  • 3K5K · Discovery of a 2,4-diamino-7-aminoalkoxy-quinazoline as a potent inhibitor of histone… · DXQ A2000 · binds ASP1074, ALA1077, ASP1078, ARG1080, ASP1083, SER1084, TYR1085, LEU1086 and 9 more

Residues it binds most

ASP 4, PHE 4, TYR 4, ARG 4, ALA 4, CYS 4, ILE 4, LEU 4, LYS 4, SER 4 (residue and the binding sites it lines).

Found with

  • SAH · S-adenosyl-L-homocysteine
  • ZN · Zinc ion
  • CL · Chloride ion
  • UNX · Unknown atom or ion

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