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Ligand · DX8

DX8 · 2-amino-6-(4-methoxyphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

DX8, 2-amino-6-(4-methoxyphenyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (C14 H11 N5 O2, 281.3 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues…

Component
DX8
Formula
C14 H11 N5 O2
Class
ligand
Structures
2
PDB entries
1

Binding sites

DX8 in 2 structures; the first of them:

  • 3JQE · Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary… · DX8 A270 · binds ARG14, SER95, ALA96, PHE97, ASP161, MET163, GLN166, PRO167 and 9 more
  • 3JQE · Crystal structure of pteridine reductase 1 (PTR1) from trypanosoma brucei in ternary… · DX8 A270 · binds ARG14, SER95, ALA96, PHE97, ASP161, MET163, GLN166, PRO167 and 9 more

Residues it binds most

LEU 8, PRO 8, ARG 8, ASP 8, CYS 8, GLN 8, GLY 8, HIS 8, MET 8, PHE 8 (residue and the binding sites it lines).

Found with

  • NAP · Nadp nicotinamide-adenine-dinucleotide phosphate
  • ACT · Acetate ion

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