GL1X · GenesisL1 explorer

Ligand · DSA

DSA · 4-hydroxy-8-methyl-6-(4,5,6-trimethoxy-1H-indole-2-carbonyl)-3,6,7,8-tetrahydro-3,6-diaza-as-indacene-2-carboxylic acid methyl ester

DSA, 4-hydroxy-8-methyl-6-(4,5,6-trimethoxy-1H-indole-2-carbonyl)-3,6,7,8-tetrahydro-3,6-diaza-as-indacene-2-carboxylic acid methyl ester (C25 H25 N3 O7, 479.5 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB…

Component
DSA
Formula
C25 H25 N3 O7
Class
ligand
Structures
4
PDB entries
2

Binding sites

DSA in 4 structures; the first of them:

  • 1DSA · (+)-duocarmycin sa covalently linked to duplex DNA, NMR, 20 structures · DSA B23 · binds DT4, DA5, DA6, DT7, DT8, DT17, DT18, DA19 and 2 more
  • 1DSM · (-)-duocarmycin SA covalently linked to duplex DNA · DSA A23 · binds DT4, DA5, DA6, DT7, DT8, DT17, DT18, DA19 and 2 more
  • 1DSA · (+)-duocarmycin sa covalently linked to duplex DNA, NMR, 20 structures · DSA B23 · binds DT4, DA5, DA6, DT7, DT8, DT17, DT18, DA19 and 2 more
  • 1DSM · (-)-duocarmycin sa covalently linked to duplex DNA · DSA A23 · binds DT4, DA5, DA6, DT7, DT8, DT17, DT18, DA19 and 2 more

Residues it binds most

DT 4, DA 4, DG 4 (residue and the binding sites it lines).

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