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Ligand · DQX

DQX · 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1H-pyrazol-4-yl)quinoxaline

DQX, 8-[3,5-difluoro-4-(morpholin-4-ylmethyl)phenyl]-2-(1-piperidin-4-yl-1H-pyrazol-4-yl)quinoxaline (C27 H28 F2 N6 O, 490.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
DQX
Formula
C27 H28 F2 N6 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

DQX in 2 structures; the first of them:

  • 5UT4 · JAK2 JH2 in complex with NVP-BSK805 · DQX A901 · binds LEU551, GLY552, GLN553, ILE559, LEU579, GLU627, PHE628, VAL629 and 9 more
  • 5UT4 · JAK2 JH2 in complex with nvp-BSK805 · DQX A901 · binds LEU551, GLY552, GLN553, ILE559, LEU579, GLU627, PHE628, VAL629 and 9 more

Residues it binds most

LEU 2, GLY 2, LYS 2, PHE 2, SER 2, ASP 2, GLN 2, GLU 2, ILE 2, THR 2 (residue and the binding sites it lines).

Found with

  • DMS · Dimethyl sulfoxide
  • GOL · Glycerol

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