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Ligand · DP9

DP9 · L-n(omega)-nitroarginine-(4R)-amino-L-proline amide

DP9, L-n(omega)-nitroarginine-(4R)-amino-L-proline amide (C11 H22 N8 O4, 330.3 g/mol), in the MolNFT structures on GenesisL1: bound in 12 records (6 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds…

Component
DP9
Formula
C11 H22 N8 O4
Class
ligand
Structures
12
PDB entries
6

Binding sites

DP9 in 12 structures; the first of them:

  • 1P6J · Rat neuronal NOS heme domain with L-N(omega)-nitroarginine-(4R)-amino-L-proline amide… · DP9 A799 · binds GLN478, PRO565, VAL567, PHE584, SER585, GLY586, TRP587, TYR588 and 4 more
  • 1P6N · Bovine endothelial NOS heme domain with L-N(omega)-nitroarginine-(4R)-amino-L-proline… · DP9 A799 · binds VAL106, GLN249, ARG252, PRO336, VAL338, PHE355, SER356, GLY357 and 6 more
  • 1ZZQ · Rat nNOS D597N mutant with L-N(omega)-Nitroarginine-(4R)-amino-L-proline amide bound · DP9 A799 · binds MET336, GLN478, ARG481, PRO565, VAL567, PHE584, SER585, GLY586 and 6 more
  • 1ZZR · Rat nNOS D597N/M336V double mutant with L-N(omega)-Nitroarginine-(4R)-amino-L-proline… · DP9 A799 · binds GLN478, ARG481, PRO565, VAL567, PHE584, SER585, GLY586, TRP587 and 4 more
  • 1ZZS · Bovine eNOS N368D single mutant with L-N(omega)-Nitroarginine-(4R)-Amino-L-Proline Amide… · DP9 A799 · binds GLN249, ARG252, PRO336, VAL338, PHE355, SER356, GLY357, TRP358 and 5 more
  • 1ZZT · Bovine eNOS N368D/V106M double mutant with L-N(omega)-Nitroarginine-(4R)-Amino-L-Proline… · DP9 A799 · binds GLN249, ARG252, PRO336, VAL338, PHE355, SER356, GLY357, TRP358 and 5 more
  • 1P6J · Rat neuronal nos heme domain with L-N(OMEGA)-nitroarginine-(4R)-amino- L-proline amide… · DP9 A799 · binds GLN478, PRO565, VAL567, PHE584, SER585, GLY586, TRP587, TYR588 and 4 more
  • 1P6N · Bovine endothelial nos heme domain with L-N(OMEGA)-nitroarginine-(4R)- amino-L-proline… · DP9 A799 · binds VAL106, GLN249, ARG252, PRO336, VAL338, PHE355, SER356, GLY357 and 6 more
  • 1ZZQ · Rat nnos D597N mutant with L-N(OMEGA)-nitroarginine-(4R)-amino-L- proline amide bound · DP9 A799 · binds MET336, GLN478, ARG481, PRO565, VAL567, PHE584, SER585, GLY586 and 6 more
  • 1ZZR · Rat nnos D597N/M336V double mutant with L-N(OMEGA)-nitroarginine-(4R)- amino-L-proline… · DP9 A799 · binds GLN478, ARG481, PRO565, VAL567, PHE584, SER585, GLY586, TRP587 and 4 more
  • 1ZZS · Bovine enos N368D single mutant with L-N(OMEGA)-nitroarginine-(4R)- amino-L-proline amide… · DP9 A799 · binds GLN249, ARG252, PRO336, VAL338, PHE355, SER356, GLY357, TRP358 and 5 more
  • 1ZZT · Bovine enos N368D/V106M double mutant with L-N(OMEGA)-nitroarginine- (4R)-amino-L-proline… · DP9 A799 · binds GLN249, ARG252, PRO336, VAL338, PHE355, SER356, GLY357, TRP358 and 5 more

Residues it binds most

TRP 24, TYR 24, VAL 24, GLN 24, GLU 24, GLY 24, PHE 24, PRO 24, SER 24, ARG 20 (residue and the binding sites it lines).

Found with

  • H4B · 5,6,7,8-tetrahydrobiopterin
  • HEM · Protoporphyrin IX containing Fe
  • ZN · Zinc ion
  • ACT · Acetate ion
  • GOL · Glycerol
  • MTL · D-mannitol
  • CAC · Cacodylate ion
  • TFA · trifluoroacetic acid

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