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Ligand · DP6

DP6 · (3R)-3-hydroxy-5-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}-3-methylpentanoic acid

DP6, (3R)-3-hydroxy-5-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}-3-methylpentanoic acid (C6 H14 O10 P2, 308.1 g/mol), in the MolNFT structures on GenesisL1: bound in 13 records (10 PDB entries). Every binding site with its residues within…

Component
DP6
Formula
C6 H14 O10 P2
Class
ligand
Structures
13
PDB entries
10

Binding sites

DP6 in 13 structures; the first of them:

  • 5GMD · Crystal structure of Sulfolobus solfataricus diphosphomevalonate decarboxylase in complex… · DP6 A1001 · binds ALA14, LYS17, TYR18, TRP19, LYS21, ASN28, SER139, GLY140 and 7 more
  • 5GME · Crystal structure of Sulfolobus solfataricus Diphosphomevalonate decarboxylase in complex… · DP6 A1001 · binds ALA14, LYS17, TYR18, TRP19, LYS21, ASN28, TYR72, SER139 and 9 more
  • 6E2T · MDDEF in complex with MVAPP · DP6 A401 · binds ALA13, LYS16, TYR17, TRP18, LYS20, ILE26, LYS71, SER106 and 11 more
  • 6E2U · MDDEF in complex with MVAPP, AMPPCP and Magnesium · DP6 A401 · binds ALA13, LYS16, TYR17, TRP18, LYS20, ILE26, LYS71, SER106 and 11 more
  • 6E2Y · MDDEF in complex with MVAPP, ADP, sulfate and cobalt. Anomalous data · DP6 A403 · binds ALA13, LYS16, TYR17, TRP18, LYS20, ILE26, SER106, GLY137 and 10 more
  • 6E2T · Mddef in complex with mvapp · DP6 A401 · binds ALA13, LYS16, TYR17, TRP18, LYS20, ILE26, LYS71, SER138 and 8 more
  • 6E2U · Mddef in complex with mvapp, amppcp and magnesium · DP6 A401 · binds ALA13, LYS16, TYR17, LYS20, ILE26, LYS71, SER106, SER138 and 8 more
  • 6E2V · Mddef in complex with mvapp, ADPBEF3 and magnesium · DP6 A403 · binds ALA13, LYS16, TYR17, LYS20, ILE26, SER106, SER138, GLY139 and 8 more
  • 6E2W · Mddef in complex with mvapp, ADP, sulfate and cobalt · DP6 A403 · binds ALA13, TYR17, TRP18, LYS20, ILE26, SER106, SER138, GLY139 and 8 more
  • 6E2Y · Mddef in complex with mvapp, ADP, sulfate and cobalt. anomalous data · DP6 A403 · binds ALA13, TYR17, TRP18, LYS20, ILE26, SER106, SER138, GLY139 and 8 more
  • 6N0Y · Crystal structure of anaerolinea thermophila mevalonate 5-phosphate decarboxylase… · DP6 A401 · binds ALA13, LYS16, TYR17, TRP18, ARG71, ALA104, SER106, SER138 and 8 more
  • 6N0Z · Crystal structure of anaerolinea thermophila mevalonate 5-phosphate decarboxylase N20K… · DP6 A401 · binds ALA13, LYS16, TYR17, TRP18, LYS20, ARG26, ARG71, SER106 and 9 more
  • 6N10 · Crystal structure of arabidopsis thaliana mevalonate 5-diphosphate decarboxylase 1… · DP6 A501 · binds ALA19, LYS22, TYR23, TRP24, LYS26, ILE32, ARG78, SER161 and 8 more

Residues it binds most

SER 23, ARG 23, ALA 23, LYS 23, MET 22, GLY 23, TYR 23, ASP 23, TRP 16, ILE 9 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • ADP · Adenosine-5'-diphosphate
  • CO · Cobalt (II) ion
  • MG · Magnesium ion
  • ACP · Phosphomethylphosphonic acid adenylate ester
  • AMP · Adenosine monophosphate
  • AGS · Phosphothiophosphoric acid-adenylate ester
  • BEF · Beryllium trifluoride ion

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