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Ligand · DP2

DP2 · L-lysyl-N~5~-[(Z)-(2,2-dihydroxyhydrazino)(imino)methyl]-L-ornithinamide

DP2, L-lysyl-N~5~-[(Z)-(2,2-dihydroxyhydrazino)(imino)methyl]-L-ornithinamide (C12 H28 N8 O4, 348.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å, the…

Component
DP2
Formula
C12 H28 N8 O4
Class
ligand
Structures
4
PDB entries
2

Binding sites

DP2 in 4 structures; the first of them:

  • 1RS6 · Rat neuronal NOS heme domain with D-lysine-D-nitroarginine amide bound · DP2 A792 · binds MET336, LEU337, SER477, GLN478, ARG481, PRO565, VAL567, PHE584 and 7 more
  • 1RS8 · Bovine endothelial NOS heme domain with D-lysine-D-nitroarginine amide bound · DP2 A792 · binds LEU107, SER248, GLN249, PRO336, VAL338, PHE355, SER356, GLY357 and 6 more
  • 1RS6 · Rat neuronal nos heme domain with D-lysine-D-nitroarginine amide bound · DP2 A792 · binds MET336, LEU337, SER477, GLN478, ARG481, PRO565, VAL567, PHE584 and 7 more
  • 1RS8 · Bovine endothelial nos heme domain with D-lysine-D-nitroarginine amide bound · DP2 A792 · binds LEU107, SER248, GLN249, PRO336, VAL338, PHE355, SER356, GLY357 and 6 more

Residues it binds most

SER 8, TRP 8, TYR 8, GLN 8, GLU 8, GLY 8, LEU 8, PHE 8, PRO 8, VAL 8 (residue and the binding sites it lines).

Found with

  • H4B · 5,6,7,8-tetrahydrobiopterin
  • HEM · Protoporphyrin IX containing Fe
  • ZN · Zinc ion
  • ACT · Acetate ion
  • MTL · D-mannitol
  • CAC · Cacodylate ion
  • GOL · Glycerol

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