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Ligand · DL1

DL1 · N-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1H-pyrazol-5-yl)pyridine-2-carboxamide

DL1, N-[2-methoxy-4-(morpholin-4-yl)phenyl]-6-(1H-pyrazol-5-yl)pyridine-2-carboxamide (C20 H21 N5 O3, 379.4 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries). Every binding site with its residues within 4.5…

Component
DL1
Formula
C20 H21 N5 O3
Class
ligand
Structures
3
PDB entries
2

Binding sites

DL1 in 3 structures; the first of them:

  • 6EGE · Crystal structure of the unphosphorylated IRAK4 kinase domain Bound to a type I inhibitor · DL1 D501 · binds ILE185, MET192, GLY193, PHE197, VAL200, ALA211, LYS213, VAL246 and 12 more
  • 6BFN · Crystal structure of human IRAK1 · DL1 A601 · binds ILE218, PHE223, VAL226, ALA237, LYS239, VAL272, TYR288, GLY289 and 6 more
  • 6EGE · Crystal structure of the unphosphorylated IRAK4 kinase domain bound to a type I inhibitor · DL1 D501 · binds MET192, PHE197, VAL200, ALA211, VAL246, TYR262, VAL263, TYR264 and 7 more

Residues it binds most

VAL 6, ASP 6, GLY 6, TYR 6, ALA 6, LEU 6, MET 4, PRO 6, PHE 4, SER 4 (residue and the binding sites it lines).

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