Ligand · DK7

DK7 · N-[(1S,2S)-1-[(3R,6R)-6-(cyclohexylmethoxy)morpholin-3-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]acetamide

DK7, N-[(1S,2S)-1-[(3R,6R)-6-(cyclohexylmethoxy)morpholin-3-yl]-3-(3,5-difluorophenyl)-1-hydroxypropan-2-yl]acetamide (C22 H32 F2 N2 O4, 426.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component: DK7
Formula: C22 H32 F2 N2 O4
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

DK7 in 2 structures; the first of them:

6BFW · BACE crystal structure with hydroxy morpholine inhibitor · DK7 A401 · binds GLN12, LEU30, ASP32, GLY34, SER35, VAL69, PRO70, TYR71 and 15 more
6BFW · Bace crystal structure with hydroxy morpholine inhibitor · DK7 A401 · binds LEU30, ASP32, GLY34, SER35, VAL69, TYR71, THR72, GLY74 and 11 more

Residues it binds most

ILE 4, GLY 4, ASP 4, THR 4, TYR 4, GLN 2, LEU 4, PHE 4, SER 4, TRP 4 (residue and the binding sites it lines).

Found with

GOL · Glycerol

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