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Ligand · DGF

DGF · (2R,5R)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-5-[(2R)-tetrahydrofuran-2-yl]-2,5-dihydro-1,3-thiazole-4-carboxylic acid

DGF, (2R,5R)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-5-[(2R)-tetrahydrofuran-2-yl]-2,5-dihydro-1,3-thiazole-4-carboxylic acid (C12 H17 N O5 S, 287.3 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries). Every…

Component
DGF
Formula
C12 H17 N O5 S
Class
ligand
Structures
3
PDB entries
2

Binding sites

DGF in 3 structures; the first of them:

  • 5DUJ · Crystal structure of ldtMt2 in complex with Faropenem adduct · DGF A503 · binds TYR318, SER331, GLY332, VAL333, HIS352, GLY353, CYS354
  • 6PSG · Crystal Structure of Class D Beta-lactamase OXA-48 with Faropenem · DGF A302 · binds ALA69, SER70, ILE102, SER118, VAL120, LEU158, THR209, GLY210 and 3 more
  • 6PSG · Crystal structure of class D beta-lactamase oxa-48 with faropenem · DGF A302 · binds ALA69, SER70, ILE102, SER118, VAL120, LEU158, THR209, GLY210 and 3 more

Residues it binds most

SER 9, LEU 8, GLY 10, TYR 10, VAL 10, ALA 8, ARG 8, ILE 8, THR 8, TRP 6 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion
  • GOL · Glycerol
  • SO4 · Sulfate ion
  • BME · Beta-mercaptoethanol

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