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Ligand · DFM

DFM · N-acetyl-L-phenylalanyl-4-[difluoro(phosphono)methyl]-L-phenylalaninamide

DFM, N-acetyl-L-phenylalanyl-4-[difluoro(phosphono)methyl]-L-phenylalaninamide (C21 H24 F2 N3 O6 P, 483.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å…

Component
DFM
Formula
C21 H24 F2 N3 O6 P
Class
ligand
Structures
2
PDB entries
1

Binding sites

DFM in 2 structures; the first of them:

  • 2CMC · Structural Basis for Inhibition of Protein Tyrosine Phosphatase 1B by Isothiazolidi… · DFM A1281 · binds ARG45, TYR46, ARG47, ASP48, VAL49, ASP181, PHE182, CYS215 and 7 more
  • 2CMC · Structural basis for inhibition of protein tyrosine phosphatase 1B by isothiazolidinone… · DFM A1281 · binds ARG45, TYR46, ARG47, ASP48, VAL49, ASP181, PHE182, CYS215 and 7 more

Residues it binds most

ARG 2, ASP 2, GLY 2, ALA 2, CYS 2, GLN 2, ILE 2, PHE 2, SER 2, TYR 2 (residue and the binding sites it lines).

Found with

  • SO4 · Sulfate ion
  • BOG · octyl beta-D-glucopyranoside

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