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Ligand · D7P

D7P · D-phenylalanyl-N~5~-[(2,2-dihydroxyhydrazino)(imino)methyl]-D-ornithinamide

D7P, D-phenylalanyl-N~5~-[(2,2-dihydroxyhydrazino)(imino)methyl]-D-ornithinamide (C15 H25 N7 O4, 367.4 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å…

Component
D7P
Formula
C15 H25 N7 O4
Class
ligand
Structures
4
PDB entries
2

Binding sites

D7P in 4 structures; the first of them:

  • 1RS7 · Rat neuronal NOS heme domain with D-phenylalanine-D-nitroarginine amide bound · D7P A797 · binds MET336, LEU337, SER477, GLN478, ARG481, PRO565, VAL567, ASN569 and 9 more
  • 1RS9 · Bovine endothelial NOS heme domain with D-phenylalanine-D-nitroarginine amide bound · D7P A797 · binds VAL106, LEU107, SER248, GLN249, ARG252, PRO336, VAL338, PHE355 and 8 more
  • 1RS7 · Rat neuronal nos heme domain with D-phenylalanine-D-nitroarginine amide bound · D7P A797 · binds MET336, LEU337, SER477, GLN478, ARG481, PRO565, VAL567, ASN569 and 9 more
  • 1RS9 · Bovine endothelial nos heme domain with D-phenylalanine-D- nitroarginine amide bound · D7P A797 · binds VAL106, LEU107, SER248, GLN249, ARG252, PRO336, VAL338, PHE355 and 8 more

Residues it binds most

TRP 8, SER 8, TYR 8, VAL 8, ARG 8, GLN 8, GLU 8, GLY 8, LEU 8, PHE 8 (residue and the binding sites it lines).

Found with

  • H4B · 5,6,7,8-tetrahydrobiopterin
  • HEM · Protoporphyrin IX containing Fe
  • ZN · Zinc ion
  • ACT · Acetate ion
  • MTL · D-mannitol
  • CAC · Cacodylate ion
  • GOL · Glycerol

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