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Ligand · COV

COV · (1S,3R,5Z,7E,14beta,17alpha)-17-[(2S,4S)-4-(2-hydroxy-2-methylpropyl)-2-methyltetrahydrofuran-2-yl]-9,10-secoandrosta-5,7,10-triene-1,3-diol

COV, (1S,3R,5Z,7E,14beta,17alpha)-17-[(2S,4S)-4-(2-hydroxy-2-methylpropyl)-2-methyltetrahydrofuran-2-yl]-9,10-secoandrosta-5,7,10-triene-1,3-diol (C28 H44 O4, 444.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
COV
Formula
C28 H44 O4
Class
ligand
Structures
2
PDB entries
1

Binding sites

COV in 2 structures; the first of them:

  • 3CS4 · Structure-based design of a superagonist ligand for the vitamin D nuclear receptor · COV A1 · binds TYR143, TYR147, PHE150, LEU227, LEU230, LEU233, VAL234, SER237 and 18 more
  • 3CS4 · Structure-based design of a superagonist ligand for the vitamin D nuclear receptor · COV A1 · binds TYR143, TYR147, PHE150, LEU227, LEU230, LEU233, VAL234, SER237 and 18 more

Residues it binds most

LEU 2, TYR 2, SER 2, VAL 2, HIS 2, ILE 2, ALA 2, ARG 2, CYS 2, MET 2 (residue and the binding sites it lines).

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