GL1X · GenesisL1 explorer

Ligand · COT

COT · Coa-S-acetyl tryptamine

COT, Coa-S-acetyl tryptamine (C33 H48 N9 O17 P3 S, 967.8 g/mol), in the MolNFT structures on GenesisL1: bound in 8 records (4 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found…

Component
COT
Formula
C33 H48 N9 O17 P3 S
Class
ligand
Structures
8
PDB entries
4

Binding sites

COT in 8 structures; the first of them:

  • 1CJW · Serotonin N-acetyltransferase complexed with a bisubstrate analog · COT A400 · binds ALA55, PHE56, SER60, ASN62, CYS63, PRO64, HIS122, ALA123 and 21 more
  • 1IB1 · Crystal structure of the 14-3-3 ZETA:SEROTONIN N-acetyltransferase complex · COT E401 · binds ALA55, PHE56, SER60, ASN62, CYS63, PRO64, HIS122, ALA123 and 22 more
  • 1KUY · X-ray Crystallographic Studies of Serotonin N-acetyltransferase Catalysis and Inhibition · COT A901 · binds ALA55, PHE56, SER60, ASN62, CYS63, PRO64, HIS122, ALA123 and 22 more
  • 1L0C · Investigation of the Roles of Catalytic Residues in Serotonin N-Acetyltransferase · COT A900 · binds ALA55, PHE56, SER60, ASN62, CYS63, PRO64, HIS122, ALA123 and 20 more
  • 1CJW · Serotonin N-acetyltransferase complexed with a bisubstrate analog · COT A400 · binds ALA55, PHE56, SER60, ASN62, CYS63, PRO64, HIS122, ALA123 and 21 more
  • 1IB1 · Crystal structure of the 14-3-3 ZETA:SEROTONIN N-acetyltransferase complex · COT E401 · binds ALA55, PHE56, SER60, ASN62, CYS63, PRO64, HIS122, ALA123 and 22 more
  • 1KUY · X-ray crystallographic studies of serotonin N-acetyltransferase catalysis and inhibition · COT A901 · binds ALA55, PHE56, SER60, ASN62, CYS63, PRO64, HIS122, ALA123 and 22 more
  • 1L0C · Investigation of the roles of catalytic residues in serotonin N- acetyltransferase · COT A900 · binds ALA55, PHE56, SER60, ASN62, CYS63, PRO64, HIS122, ALA123 and 20 more

Residues it binds most

ALA 14, PHE 14, LEU 14, ARG 14, CYS 14, GLN 14, GLY 14, SER 14, VAL 14, ASN 14 (residue and the binding sites it lines).

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.