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Ligand · COK

COK · [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R)-3-hydroxy-4-{[3-({2-[(2-hydroxyethyl)dithio]ethyl}amino)-3-oxopropyl]amino}-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate

COK, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R)-3-hydroxy-4-{[3-({2-[(2-hydroxyethyl)dithio]ethyl}amino)-3-oxopropyl]amino}-2,2-dimethyl-4-oxobutyl dihydrogen diphosphate (C23 H40 N7…

Component
COK
Formula
C23 H40 N7 O17 P3 S2
Class
ligand
Structures
8
PDB entries
4

Binding sites

COK in 8 structures; the first of them:

  • 2GES · Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with a coenzyme A… · COK A401 · binds GLY39, LEU40, VAL99, ALA100, LYS103, SER104, THR105, ARG108 and 19 more
  • 2GET · Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with a coenzyme A… · COK A401 · binds GLY39, LEU40, VAL99, ALA100, LYS103, SER104, THR105, ARG108 and 20 more
  • 2GEU · Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with a coenzyme A… · COK A401 · binds GLY39, LEU40, VAL99, ALA100, LYS103, SER104, THR105, ARG108 and 20 more
  • 2GEV · Pantothenate kinase from Mycobacterium tuberculosis (MtPanK) in complex with a coenzyme A… · COK A401 · binds GLY39, LEU40, VAL99, ALA100, LYS103, SER104, THR105, ARG108 and 22 more
  • 2GES · Pantothenate kinase from mycobacterium tuberculosis (mtpank) in complex with a coenzyme a… · COK A401 · binds GLY39, LEU40, VAL99, ALA100, LYS103, SER104, THR105, ARG108 and 19 more
  • 2GET · Pantothenate kinase from mycobacterium tuberculosis (mtpank) in complex with a coenzyme a… · COK A401 · binds GLY39, LEU40, VAL99, ALA100, LYS103, SER104, THR105, ARG108 and 20 more
  • 2GEU · Pantothenate kinase from mycobacterium tuberculosis (mtpank) in complex with a coenzyme a… · COK A401 · binds GLY39, LEU40, VAL99, ALA100, LYS103, SER104, THR105, ARG108 and 20 more
  • 2GEV · Pantothenate kinase from mycobacterium tuberculosis (mtpank) in complex with a coenzyme a… · COK A401 · binds GLY39, LEU40, VAL99, ALA100, LYS103, SER104, THR105, ARG108 and 22 more

Residues it binds most

LEU 8, TYR 8, PHE 8, ALA 8, ARG 8, GLY 8, ILE 8, LYS 8, ASN 8, ASP 8 (residue and the binding sites it lines).

Found with

  • GOL · Glycerol
  • TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol

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