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Ligand · BR2

BR2 · 2,6-difluoro-N-[(5S)-3-methoxy-5H-pyrazolo[3,4-b]pyridin-5-yl]-3-[(phenylsulfonyl)amino]benzamide

BR2, 2,6-difluoro-N-[(5S)-3-methoxy-5H-pyrazolo[3,4-b]pyridin-5-yl]-3-[(phenylsulfonyl)amino]benzamide (C20 H15 F2 N5 O4 S, 459.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its…

Component
BR2
Formula
C20 H15 F2 N5 O4 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

BR2 in 2 structures; the first of them:

  • 3SKC · Human B-Raf Kinase in Complex with an Amide Linked Pyrazolopyridine Inhibitor · BR2 A801 · binds ILE463, VAL471, ALA481, VAL482, LYS483, LEU505, THR508, ILE513 and 12 more
  • 3SKC · Human B-RAF kinase in complex with an amide linked pyrazolopyridine inhibitor · BR2 A801 · binds ILE463, VAL471, ALA481, VAL482, LYS483, LEU505, THR508, ILE513 and 12 more

Residues it binds most

ILE 4, PHE 4, LEU 4, GLY 4, THR 4, VAL 4, ALA 4, ASP 4, CYS 4, GLN 4 (residue and the binding sites it lines).

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