GL1X · GenesisL1 explorer

Ligand · BIQ

BIQ · Benzyl [12-(2-amino-2-oxoethyl)-4-nitro-10,13-dioxo-15-[(propylamino)carbonyl]-2-oxa-11,14-diazatricyclo[15 .2.2.1~3,7~]docosa-1(19),3(22),4,6,17,20-hexaen-9-yl]carbamate

BIQ, Benzyl [12-(2-amino-2-oxoethyl)-4-nitro-10,13-dioxo-15-[(propylamino)carbonyl]-2-oxa-11,14-diazatricyclo[15 .2.2.1~3,7~]docosa-1(19),3(22),4,6,17,20-hexaen-9-yl]carbamate (C33 H36 N6 O9, 660.7 g/mol), in the MolNFT structures on…

Component
BIQ
Formula
C33 H36 N6 O9
Class
ligand
Structures
2
PDB entries
1

Binding sites

BIQ in 2 structures; the first of them:

  • 2GPL · TMC-95 based biphenyl-ether macrocycles: specific proteasome inhibitors · BIQ H1000 · binds THR1, ARG19, SER20, THR21, GLN22, ALA27, LYS33, GLY45 and 13 more
  • 2GPL · Tmc-95 based biphenyl-ether macrocycles: specific proteasome inhibitors · BIQ H1000 · binds THR1, ARG19, SER20, THR21, GLN22, ALA27, LYS33, GLY45 and 13 more

Residues it binds most

ALA 4, THR 4, ARG 4, ASP 4, GLY 4, SER 4, CYS 4, GLN 4, ILE 4, LEU 4 (residue and the binding sites it lines).

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