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Ligand · BFK

BFK · [3-[[5-methyl-2-[[3-(4-methylpiperazin-1-yl)-5-methylsulfonyl-phenyl]amino]pyrimidin-4-yl]amino]phenyl]methanol

BFK, [3-[[5-methyl-2-[[3-(4-methylpiperazin-1-yl)-5-methylsulfonyl-phenyl]amino]pyrimidin-4-yl]amino]phenyl]methanol (C24 H30 N6 O3 S, 482.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding…

Component
BFK
Formula
C24 H30 N6 O3 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

BFK in 2 structures; the first of them:

  • 6ELR · Human jak1 kinase domain in complex with compound 7 · BFK A1201 · binds ARG879, LEU881, GLY882, VAL889, ALA906, VAL938, MET956, GLU957 and 13 more
  • 6ELR · Human JAK1 kinase domain in complex with compound 7 · BFK A1201 · binds ARG879, LEU881, GLY882, VAL889, ALA906, MET956, GLU957, PHE958 and 10 more

Residues it binds most

GLY 4, LEU 4, ARG 4, GLU 4, SER 4, VAL 4, ALA 4, ASN 4, MET 4, PHE 4 (residue and the binding sites it lines).

Found with

  • NA · Sodium ion

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