AVU · [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl [(2R,3R,4R)-4-fluoro-3-hydroxytetrahydrofuran-2-yl]methyl dihydrogen diphosphate

Binding sites

AVU in 12 structures; the first of them:

• 3I9M · Crystal structure of human CD38 complexed with an analog ara-2'F-ADPR · AVU A301 · binds TRP125, SER126, ARG127, LYS129, LEU145, GLU146, ALA154, ASP155 and 9 more
• 3OFS · Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy… · AVU A301 · binds LEU124, TRP125, SER126, ARG127, LYS129, LEU145, ASP155, ASP156 and 9 more
• 3P5S · Structural insights into the catalytic mechanism of CD38: Evidence for a conformationally… · AVU A280 · binds PHE117, TRP118, SER119, LYS120, LYS122, LEU137, GLU138, ASP147 and 7 more
• 3ZWP · Crystal structure of ADP ribosyl cyclase complexed with ara-2'F-ADP- ribose at 2.1… · AVU A301 · binds PHE76, TRP77, SER78, GLY79, LEU97, GLU98, ASN107, TRP140 and 6 more
• 3ZWV · Crystal structure of ADP-ribosyl cyclase complexed with ara-2'F-ADP- ribose at 2.3… · AVU A301 · binds PHE76, TRP77, SER78, GLY79, LEU97, GLU98, ASN107, TRP140 and 6 more
• 3ZWW · Crystal structure of ADP-ribosyl cyclase complexed with ara-2'F-ADP- ribose at 2.3… · AVU A301 · binds PHE76, TRP77, SER78, GLY79, LEU97, GLU98, ASN107, SER108 and 7 more
• 3I9M · Crystal structure of human CD38 complexed with an analog ara-2'F-adpr · AVU A301 · binds TRP125, SER126, ARG127, LYS129, LEU145, GLU146, ALA154, ASP155 and 9 more
• 3OFS · Dynamic conformations of the CD38-mediated NAD cyclization captured using multi-copy… · AVU A301 · binds LEU124, TRP125, SER126, ARG127, LYS129, LEU145, ASP155, ASP156 and 9 more

Residues it binds most

SER 68, PHE 68, TRP 68, GLU 68, LEU 68, ARG 64, GLY 52, ASN 40, ASP 16, LYS 20 (residue and the binding sites it lines).

Found with

• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
• SO4 · Sulfate ion
• GOL · Glycerol