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Ligand · AVR

AVR · (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one

AVR, (2R)-2-amino-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]propan-1-one (C13 H17 N3 O, 231.3 g/mol), in the MolNFT structures on GenesisL1: bound in 6 records (3 PDB entries). Every binding site with its residues within 4.5 Å, the…

Component
AVR
Formula
C13 H17 N3 O
Class
ligand
Structures
6
PDB entries
3

Binding sites

AVR in 6 structures; the first of them:

  • 3IJG · Macrophage Migration Inhibitory Factor (MIF) Bound to the (R)-Stereoisomer of AV1013 · AVR C200 · binds PHE49, TYR95, GLN35, TYR36, TRP108, PHE113
  • 3IJJ · Ternary Complex of Macrophage Migration Inhibitory Factor (MIF) Bound Both to… · AVR C200 · binds PHE49, TYR95, GLN35, TYR36, TRP108, PHE113
  • 4GRR · characterization of N- and C- terminus mutants of human MIF · AVR B201 · binds PRO1, GLN37, TYR38, TRP110, PHE115, PHE51, TYR97
  • 3IJG · Macrophage migration inhibitory factor (mif) bound to the (R)- stereoisomer of AV1013 · AVR C200 · binds PHE49, TYR95, GLN35, TYR36, TRP108, PHE113
  • 3IJJ · Ternary complex of macrophage migration inhibitory factor (mif) bound both to… · AVR C200 · binds PHE49, TYR95, GLN35, TYR36, TRP108, PHE113
  • 4GRR · Characterization of N- and C- terminus mutants of human mif · AVR B201 · binds PRO1, GLN37, TYR38, TRP110, PHE115, PHE51, TYR97

Residues it binds most

PHE 6, TYR 6, GLN 6, TRP 6, PRO 2 (residue and the binding sites it lines).

Found with

  • CL · Chloride ion
  • EN1 · (2E)-2-hydroxy-3-(4-hydroxyphenyl)prop-2-enoic acid
  • ENO · 3-(4-hydroxy-phenyl)pyruvic acid
  • SO4 · Sulfate ion

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