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Ligand · A3T

A3T · 3'-deoxy-3'-(L-threonylamino)adenosine

A3T, 3'-deoxy-3'-(L-threonylamino)adenosine (C14 H21 N7 O5, 367.4 g/mol), in the MolNFT structures on GenesisL1: bound in 20 records (10 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component
A3T
Formula
C14 H21 N7 O5
Class
ligand
Structures
20
PDB entries
10

Binding sites

A3T in 20 structures; the first of them:

  • 3PD3 · Crystal structure of the editing domain of threonyl-tRNA synthetase from Pyrococcus… · A3T A148 · binds ALA19, LEU20, ILE43, SER44, VAL45, TYR79, PRO80, PHE81 and 14 more
  • 4RRA · N-terminal editing domain of threonyl-tRNA synthetase from Aeropyrum pernix with L-Thr3AA… · A3T A201 · binds ALA19, LEU20, THR40, THR41, VAL42, TYR73, PRO74, TYR75 and 13 more
  • 4RRB · N-terminal editing domain of threonyl-tRNA synthetase from Aeropyrum pernix with L-Thr3AA… · A3T A500 · binds ALA19, LEU20, THR40, THR41, VAL42, TYR73, PRO74, TYR75 and 12 more
  • 4RRC · N-terminal editing domain of threonyl-tRNA synthetase from Aeropyrum pernix with L-Thr3AA… · A3T A500 · binds ALA19, LEU20, THR40, THR41, VAL42, TYR73, PRO74, TYR75 and 12 more
  • 4RRD · N-terminal editing domain of threonyl-tRNA synthetase from Aeropyrum pernix with L-Thr3AA… · A3T A501 · binds ALA19, LEU20, THR40, THR41, VAL42, TYR73, PRO74, TYR75 and 13 more
  • 4RRG · Editing domain of threonyl-tRNA synthetase from Methanococcus jannaschii with L-Thr3AA · A3T A501 · binds THR23, ILE25, ILE44, ALA45, VAL46, TYR80, PRO81, TYR82 and 10 more
  • 4RRI · K116M mutant of N-terminal editing domain of threonyl-tRNA synthetase from Aeropyrum… · A3T A501 · binds ALA19, LEU20, THR40, THR41, VAL42, TYR73, PRO74, TYR75 and 12 more
  • 4RRK · Y115A mutant of N-terminal editing domain of threonyl-tRNA synthetase from Aeropyrum… · A3T A501 · binds ALA19, LEU20, THR40, THR41, VAL42, TYR73, PRO74, TYR75 and 13 more
  • 4RRM · E129A mutant of N-terminal editing domain of threonyl-tRNA synthetase from Aeropyrum… · A3T A501 · binds ALA19, LEU20, THR40, THR41, VAL42, TYR73, PRO74, TYR75 and 12 more
  • 4RRR · K121M mutant of N-terminal editing domain of threonyl-tRNA synthetase from Pyrococcus… · A3T A201 · binds ALA19, LEU20, ILE43, SER44, VAL45, TYR79, PRO80, PHE81 and 15 more
  • 3PD3 · Crystal structure of the editing domain of threonyl-tRNA synthetase from pyrococcus… · A3T A148 · binds ALA19, LEU20, ILE43, SER44, VAL45, TYR79, PRO80, PHE81 and 14 more
  • 4RRA · N-terminal editing domain of threonyl-tRNA synthetase from aeropyrum pernix with L-THR3AA… · A3T A201 · binds ALA19, LEU20, THR40, THR41, VAL42, TYR73, PRO74, TYR75 and 13 more
  • 4RRB · N-terminal editing domain of threonyl-tRNA synthetase from aeropyrum pernix with L-THR3AA… · A3T A500 · binds ALA19, LEU20, THR40, THR41, VAL42, TYR73, PRO74, TYR75 and 12 more
  • 4RRC · N-terminal editing domain of threonyl-tRNA synthetase from aeropyrum pernix with L-THR3AA… · A3T A500 · binds ALA19, LEU20, THR40, THR41, VAL42, TYR73, PRO74, TYR75 and 12 more
  • 4RRD · N-terminal editing domain of threonyl-tRNA synthetase from aeropyrum pernix with L-THR3AA… · A3T A501 · binds ALA19, LEU20, THR40, THR41, VAL42, TYR73, PRO74, TYR75 and 13 more
  • 4RRG · Editing domain of threonyl-tRNA synthetase from methanococcus jannaschii with L-THR3AA · A3T A501 · binds THR23, ILE25, ILE44, ALA45, VAL46, TYR80, PRO81, TYR82 and 10 more
  • 4RRI · K116M mutant of N-terminal editing domain of threonyl-tRNA synthetase from aeropyrum… · A3T A501 · binds ALA19, LEU20, THR40, THR41, VAL42, TYR73, PRO74, TYR75 and 12 more
  • 4RRK · Y115A mutant of N-terminal editing domain of threonyl-tRNA synthetase from aeropyrum… · A3T A501 · binds ALA19, LEU20, THR40, THR41, VAL42, TYR73, PRO74, TYR75 and 13 more
  • 4RRM · E129A mutant of N-terminal editing domain of threonyl-tRNA synthetase from aeropyrum… · A3T A501 · binds ALA19, LEU20, THR40, THR41, VAL42, TYR73, PRO74, TYR75 and 12 more
  • 4RRR · K121M mutant of N-terminal editing domain of threonyl-tRNA synthetase from pyrococcus… · A3T A201 · binds ALA19, LEU20, ILE43, SER44, VAL45, TYR79, PRO80, PHE81 and 15 more

Residues it binds most

ALA 28, LEU 28, TYR 28, PRO 28, PHE 28, GLY 28, THR 16, VAL 28, HIS 24, LYS 22 (residue and the binding sites it lines).

Found with

  • MG · Magnesium ion
  • CL · Chloride ion

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