Ligand · A1AM2

A1AM2 · N-{(1P)-5'-({(17E)-18-[(3P)-4-{[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]carbamoyl}-3-(4-chloro-2-fluorophenyl)-1H-pyrrol-2-yl]-16-oxo-3,6,9,12-tetraoxa-15-azaoctadec-17-en-1-yl}carbamoyl)-2'-fluoro-4-[(3R,5S)-3,4,5-trimethylpiperazin-1-yl][1,1'-biphenyl]-3-yl}-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide

A1AM2, N-{(1P)-5'-({(17E)-18-[(3P)-4-{[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]carbamoyl}-3-(4-chloro-2-fluorophenyl)-1H-pyrrol-2-yl]-16-oxo-3,6,9,12-tetraoxa-15-azaoctadec-17-en-1-yl}carbamoyl)-2'-fluoro-4-[(3R,5S)-3,4,5-trime…

Component: A1AM2
Formula: C60 H63 Cl2 F6 N9 O10
Class: ligand
Structures: 1
PDB entries: 1

Binding sites

A1AM2 in 1 structure; the first of them:

9B9H · Crystal structure of the ternary complex of DCAF1 and WDR5 with PROTAC, OICR-40333 · A1AM2 A1401 · binds CYS1099, THR1139, HIS1140, THR1155, TRP1156, TYR1181, ARG1225, CYS1227 and 38 more

Residues it binds most

PHE 1, SER 1, CYS 1, TYR 1, VAL 1, ALA 1, ASP 1, ILE 1, LEU 1, ARG 1 (residue and the binding sites it lines).

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