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Ligand · 933

933 · 2-cyclopropyl-N-[(2S)-3,3-dimethylbutan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide

933, 2-cyclopropyl-N-[(2S)-3,3-dimethylbutan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (C16 H22 N4 O, 286.4 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within…

Component
933
Formula
C16 H22 N4 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

933 in 2 structures; the first of them:

  • 4HVD · JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic… · 933 A1202 · binds LEU828, GLY829, VAL836, ALA853, VAL884, MET902, GLU903, TYR904 and 8 more
  • 4HVD · JAK3 kinase domain in complex with 2-cyclopropyl-5H-PYRROLO[2,3- B]PYRAZINE-7-carboxylic… · 933 A1202 · binds LEU828, GLY829, VAL836, ALA853, VAL884, MET902, GLU903, TYR904 and 8 more

Residues it binds most

LEU 2, ALA 2, GLY 2, VAL 2, ARG 2, ASN 2, ASP 2, CYS 2, GLU 2, MET 2 (residue and the binding sites it lines).

Found with

  • PHU · 1-phenylurea

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