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Ligand · 8VM

8VM · 5-(3-{4-[(2S)-2-hydroxy-3,3-dimethylbutoxy]-3-methylphenyl}pentan-3-yl)-3-methyl-N-(1H-tetrazol-5-yl)thiophene-2-carboxamide

8VM, 5-(3-{4-[(2S)-2-hydroxy-3,3-dimethylbutoxy]-3-methylphenyl}pentan-3-yl)-3-methyl-N-(1H-tetrazol-5-yl)thiophene-2-carboxamide (C25 H35 N5 O3 S, 485.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry).…

Component
8VM
Formula
C25 H35 N5 O3 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

8VM in 2 structures; the first of them:

  • 5V39 · Crystal structure of human vitamin D receptor ligand binding domain in complex with a VDRM · 8VM A501 · binds TYR143, TYR147, PHE150, LEU227, LEU230, ALA231, LEU233, VAL234 and 20 more
  • 5V39 · Crystal structure of human vitamin D receptor ligand binding domain in complex with a vdrm · 8VM A501 · binds TYR143, PHE150, LEU227, LEU230, ALA231, LEU233, VAL234, TYR236 and 16 more

Residues it binds most

LEU 2, TYR 2, SER 2, VAL 2, HIS 2, PHE 2, ALA 2, ARG 2, CYS 2, ILE 2 (residue and the binding sites it lines).

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