GL1X · GenesisL1 explorer

Ligand · 8QZ

8QZ · ~{N}-[3,5-diethyl-1-[2-[2-(2-methoxyethoxy) ethoxy]ethyl]pyrazol-4-yl]-2-[[2-methoxy-4-[4-(2-methoxyethanoyl)piperazin-1-yl]phenyl]amino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide

8QZ, ~{N}-[3,5-diethyl-1-[2-[2-(2-methoxyethoxy) ethoxy]ethyl]pyrazol-4-yl]-2-[[2-methoxy-4-[4-(2-methoxyethanoyl)piperazin-1-yl]phenyl]amino]-5,6-dihydropyrimido[4,5-e]indolizine-7-carboxamide (C39 H53 N9 O7, 759.9 g/mol), in the MolNFT…

Component
8QZ
Formula
C39 H53 N9 O7
Class
ligand
Structures
2
PDB entries
1

Binding sites

8QZ in 2 structures; the first of them:

  • 5NA0 · TTK kinase domain in complex with a PEG-linked pyrimido-indolizine · 8QZ A901 · binds ILE531, SER533, GLY534, SER537, VAL539, GLN541, ALA551, LYS553 and 17 more
  • 5NA0 · Ttk kinase domain in complex with a peg-linked pyrimido-indolizine · 8QZ A901 · binds ILE531, SER533, GLY534, SER537, VAL539, GLN541, ALA551, LYS553 and 17 more

Residues it binds most

ILE 2, SER 2, ASN 2, ASP 2, GLU 2, GLY 2, LYS 2, MET 2, VAL 2, ALA 2 (residue and the binding sites it lines).

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