GL1X · GenesisL1 explorer

Ligand · 85K

85K · (7-{(5M)-5-[3-chloro-6-cyano-5-(cyclopropyloxy)-2-fluorophenyl]-1-methyl-1H-pyrazol-4-yl}-4-oxo-3,4-dihydrophthalazin-1-yl)methanaminium

85K, (7-{(5M)-5-[3-chloro-6-cyano-5-(cyclopropyloxy)-2-fluorophenyl]-1-methyl-1H-pyrazol-4-yl}-4-oxo-3,4-dihydrophthalazin-1-yl)methanaminium (C23 H19 Cl F N6 O2 +1, 465.9 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records…

Component
85K
Formula
C23 H19 Cl F N6 O2 +1
Class
ligand
Structures
2
PDB entries
1

Binding sites

85K in 2 structures; the first of them:

  • 7S1S · PRMT5/MEP50 crystal structure with MTA and MRTX-1719 bound · 85K A702 · binds PHE300, TYR304, GLN309, SER310, PRO311, LEU312, PRO314, THR323 and 12 more
  • 7S1S · PRMT5/MEP50 crystal structure with mta and mrtx-1719 bound · 85K A702 · binds PHE300, TYR304, GLN309, SER310, PRO311, LEU312, PRO314, THR323 and 12 more

Residues it binds most

LEU 2, PHE 2, GLU 2, PRO 2, SER 2, VAL 2, GLN 2, GLY 2, LYS 2, THR 2 (residue and the binding sites it lines).

Found with

  • MTA · 5'-deoxy-5'-methylthioadenosine

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