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Ligand · 84W

84W · [7-(1-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydrophthalazin-1-yl]methanaminium

84W, [7-(1-methyl-1H-pyrazol-4-yl)-4-oxo-3,4-dihydrophthalazin-1-yl]methanaminium (C13 H14 N5 O +1, 256.3 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with its residues within 4.5 Å…

Component
84W
Formula
C13 H14 N5 O +1
Class
ligand
Structures
2
PDB entries
1

Binding sites

84W in 2 structures; the first of them:

  • 7S1Q · PRMT5/MEP50 crystal structure with MTA and a phthalazi inhibitor bound (Compound 9) · 84W A702 · binds GLN309, SER310, PRO311, LEU312, PRO314, PHE327, LYS333, GLU435 and 6 more
  • 7S1Q · PRMT5/MEP50 crystal structure with mta and a phthalazinone inhibitor bound (compound 9) · 84W A702 · binds GLN309, SER310, PRO311, LEU312, PRO314, PHE327, LYS333, GLU435 and 6 more

Residues it binds most

LEU 2, GLU 2, PRO 2, SER 2, GLN 2, LYS 2, PHE 2, TRP 2, VAL 2 (residue and the binding sites it lines).

Found with

  • MTA · 5'-deoxy-5'-methylthioadenosine

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