80I · [(3~{S})-3-[[(2~{S})-2-[(4-methoxy-1~{H}-indol-2-yl) carbonylamino]-4-methyl-pentanoyl]amino]-2-oxidanylidene-4-[(3~{R})-2-oxidanylidene-3,4-dihydropyrrol-3-yl]butyl] dihydrogen phosphate

Binding sites

80I in 6 structures; the first of them:

• 7WQJ · Crystal structure of MERS main protease in complex with PF07304814 · 80I A401 · binds HIS41, LEU49, PHE143, LEU144, CYS145, GLY146, SER147, CYS148 and 10 more
• 8HVU · Crystal structure of SARS-Cov-2 main protease G15S mutant in complex with PF07304814 · 80I A401 · binds THR25, LEU27, HIS41, PHE140, LEU141, ASN142, GLY143, SER144 and 12 more
• 8IM6 · Crystal structure of HCoV 229E main protease in complex with PF07304814 · 80I A401 · binds VAL26, HIS41, TYR53, PHE139, ILE140, ASN141, GLY142, ALA143 and 13 more
• 7VVP · Crystal structure of SARS-cov-2 main protease in complex with PF07304814 · 80I B301 · binds THR26, HIS41, PHE140, LEU141, ASN142, GLY143, SER144, CYS145 and 9 more
• 7WQH · Crystal structure of hcov-NL63 main protease with PF07304814 · 80I A401 · binds HIS41, PHE139, ASN141, GLY142, ALA143, CYS144, HIS163, GLN164 and 6 more
• 7WQJ · Crystal structure of MERS main protease in complex with PF07304814 · 80I A401 · binds LEU49, PHE143, LEU144, CYS145, GLY146, SER147, CYS148, HIS166 and 9 more

Residues it binds most

HIS 9, GLN 9, LEU 8, GLY 9, CYS 9, ASN 7, GLU 9, PHE 9, ILE 4, THR 4 (residue and the binding sites it lines).