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Ligand · 7VH

7VH · 5-chloranyl-N-[5-chloranyl-2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-(1-ethylsulfonylindol-3-yl)pyrimidin-2-amine

7VH, 5-chloranyl-N-[5-chloranyl-2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-(1-ethylsulfonylindol-3-yl)pyrimidin-2-amine (C31 H37 Cl2 N7 O3 S, 658.6 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1…

Component
7VH
Formula
C31 H37 Cl2 N7 O3 S
Class
ligand
Structures
2
PDB entries
1

Binding sites

7VH in 2 structures; the first of them:

  • 7VRE · The crystal structure of EGFR T790M/C797S with the inhibitor HCD2892 · 7VH A1101 · binds LEU718, GLY719, PHE723, VAL726, ALA743, LYS745, CYS775, MET790 and 14 more
  • 7VRE · The crystal structure of EGFR T790M/C797S with the inhibitor HCD2892 · 7VH A1101 · binds LEU718, GLY719, PHE723, VAL726, ALA743, LYS745, CYS775, MET790 and 14 more

Residues it binds most

LEU 2, ASP 2, GLY 2, MET 2, ALA 2, ARG 2, ASN 2, CYS 2, GLN 2, GLU 2 (residue and the binding sites it lines).

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