GL1X · GenesisL1 explorer

Ligand · 7UN

7UN · (8R)-8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]-5,8-dihydropyrido[4,3-d]pyrimidin-7(6H)-one

7UN, (8R)-8-(4-chlorophenyl)-6-(2-methyl-2H-indazol-5-yl)-2-[(2,2,2-trifluoroethyl)amino]-5,8-dihydropyrido[4,3-d]pyrimidin-7(6H)-one (C23 H16 Cl F3 N6 O, 484.9 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB…

Component
7UN
Formula
C23 H16 Cl F3 N6 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

7UN in 2 structures; the first of them:

  • 7RWG · Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM… · 7UN A408 · binds PHE18, LEU19, PHE20, GLN190, ASP191, ARG192, GLY193, ALA194 and 5 more
  • 7RWG · "crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM… · 7UN A408 · binds PHE18, LEU19, PHE20, GLN190, ASP191, ARG192, GLY193, ALA194 and 5 more

Residues it binds most

GLY 2, ARG 2, PHE 2, ALA 2, ASP 2, GLN 2, LEU 2, TRP 2, VAL 2 (residue and the binding sites it lines).

Found with

  • SAM · S-adenosylmethionine
  • CL · Chloride ion
  • EDO · 1,2-ethanediol
  • GOL · Glycerol

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