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Ligand · 7L6

7L6 · 6,7-dimethoxy-N-(1-methylpiperidin-4-yl)-2-(morpholin-4-yl)quinazolin-4-amine

7L6, 6,7-dimethoxy-N-(1-methylpiperidin-4-yl)-2-(morpholin-4-yl)quinazolin-4-amine (C20 H29 N5 O3, 387.5 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries). Every binding site with its residues within 4.5 Å…

Component
7L6
Formula
C20 H29 N5 O3
Class
ligand
Structures
3
PDB entries
2

Binding sites

7L6 in 3 structures; the first of them:

  • 5TUZ · Structure of human GLP SET-domain (EHMT1) in complex with inhibitor MS0124 · 7L6 A3006 · binds ASP1162, ALA1165, ASP1166, ARG1168, ASP1171, LEU1174, ASP1176, CYS1186 and 5 more
  • 5TUY · Structure of human G9A set-domain (EHMT2) in complex with inhibitor MS0124 · 7L6 A1506 · binds ASP1074, ALA1077, ASP1078, ARG1080, ASP1083, LEU1086, ASP1088, CYS1098 and 3 more
  • 5TUZ · Structure of human glp set-domain (EHMT1) in complex with inhibitor MS0124 · 7L6 A3006 · binds ASP1162, ALA1165, ASP1166, ARG1168, ASP1171, LEU1174, ASP1176, CYS1186 and 4 more

Residues it binds most

ASP 6, ARG 6, ALA 6, CYS 6, LEU 6, LYS 6, PHE 6, ILE 5, TYR 2, VAL 1 (residue and the binding sites it lines).

Found with

  • ZN · Zinc ion
  • EDO · 1,2-ethanediol
  • SAM · S-adenosylmethionine

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